PEA (PhenylEthylAmine) is a neuromodulator (monoamine) in the brain involved in mood and mental alertness related to the neurotransmitter Dopamine (3,4-dihydroxy-phenethylamine). It naturally occurs in some amounts in chocolate, certain algae’s and is produced in small amount in the brain from D-Phenylalanine.Phenylethylamine is related to the following neurotransmitters and neuroactive compounds:
Dopamine (3,4-dihydroxy-phenethylamine), Tyramine (4-hydroxy-phenethylamine), Epinepinephrine (â,3,4-trihydroxy-N-methyl-phenethylamine), Ephedrine (N-methyl-â-hydroxy-amphetamine), etc.
Its chemically structural relation to these compounds account for its unique effects on mood, focus, mental alertness, and energy. However its effects are relatively short acting as it is usually broken down by the enzyme MAO-B within several hours. This makes it an ideal short-lived yet safe fast acting compound.
-Neurochemical Effects-
: Helps maintain focus, concentration, mood, alertness and effortful attention
: Increases the release of Acetylcholine (Support Memory & Cognition)
[By stimulating the AMPA glutamtergic receptors]
: Elevate mental alertness
[By suppressing the inhibitory effects of GABA-B receptors]
: Indirect activation of Dopamine autoreceptors
[By an increased efflux of newly synthesized dopamine]
-Dose-
Take 250-500 mg daily on an empty stomach.
-When can I feel it?-
Many people notice the effects within an hour to a few days.
-Works best with-
MAO B inhibitors such as Kava Kava extract (desmethoxyyangonin).
-Notes-
Do not take if you have high blood pressure, are taking any medications/supplements, or have a health conditions without your doctor’s advice.
